Dr. Paul Hagerman
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Distinguished Professor of Biochemistry & Molecular Medicine, UC Davis Health; Investigator, UC Davis MIND Institute
Dr. Paul Hagerman
Dr. Paul Hagerman is a world-renowned molecular geneticist and physician-scientist at UC Davis Health. He is a Distinguished Professor of Biochemistry and Molecular Medicine and an investigator at the UC Davis MIND Institute.
Alongside his wife, Dr. Randi Hagerman, he discovered Fragile X–associated Tremor/Ataxia Syndrome (FXTAS), a neurodegenerative disorder affecting older carriers of the FMR1 gene. His research focuses on RNA toxicity and the development of biomarkers for Fragile X–related disorders, which are among the leading heritable forms of autism and intellectual disability.
Dr. Hagerman’s work bridges molecular insights with clinical application, contributing to improved diagnosis, monitoring, and therapeutic strategies for individuals affected by fragile X–associated conditions.
Professional Highlights :
Research Experience
peer reviewed publications
Co-Discovered Fragile X–Associated Tremor/Ataxia Syndrome
Pioneering work in molecular mechanisms of FXPAC
Developing translational tools for diagnosis and therapy
Dr. Paul Hagerman Talk
Molecular/Genetic Insights: Fragile X Premutation–Associated Conditions (FXPAC)
Abstract
In this talk, Dr. Paul Hagerman will highlight key molecular and genetic mechanisms underlying Fragile X premutation–associated conditions (FXPAC). He will explore how FMR1 gene dysregulation contributes to neurological and systemic effects, offering insights into the biological underpinnings of these conditions.
RNA Toxicity: Discusses the central role of RNA toxicity in FXPAC pathogenesis.
Genotype–Phenotype: Explains relationships between FMR1 mutations and clinical presentations.
Clinical Implications: Covers how molecular discoveries inform diagnosis, monitoring, and management strategies.
Therapeutic Insights: Highlights emerging approaches and potential treatments based on molecular and genetic understanding.
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