Fragile X–associated conditions affect individuals and entire family systems, often across multiple generations. In this session, genetic counselor Susan Howell offers a practical, family-centered guide to navigating Fragile X—from understanding inheritance patterns to making informed decisions about testing and communication. The talk will clarify how FMR1 variants are passed through families, what risk looks like across relatives, and why cascade testing can be a powerful tool for identifying at-risk family members early. Attendees will learn how genetic counseling supports families in interpreting results, addressing uncertainty, and planning next steps, including reproductive options, anticipatory guidance for Fragile X–associated disorders, and connecting relatives to timely medical and developmental resources. The session also highlights the real-world, multigenerational impacts of diagnosis, emotional, logistical, and relational—and offers strategies for compassionate family communication that respects autonomy, privacy, and cultural context. Designed for clinicians, educators, advocates, and families, this talk bridges genetics with lived experience to strengthen support pathways and improve outcomes across the lifespan.